Signal transduction pathway in human polymorphonuclear leukocytes induced by a chemoattractant.
نویسندگان
چکیده
منابع مشابه
Human Polymorphonuclear Leukocytes
A B S T R A C T Acetyl glyceryl ether phosphorylcholine (AGEPC) and leukotriene B4 (LTB4) induce concentration-dependent neutrophil aggregation. On a molar basis, LTB4 is 10 to 100 times more potent than AGEPC. AGEPC-induced aggregation is attenuated by two inhibitors of arachidonate lipoxygenation, eicosatetraynoic acid and nordihydroguaiaretic acid, and to a lesser extent by the cyclooxygenas...
متن کاملArachidonate metabolism by human polymorphonuclear leukocytes
Release of arachidonic acid by the membrane phospholipase and metabolism by the 5-lipoxygenase pathway was examined in human polymorphonuclear leukocytes (PMNs). The 5-lipoxygenase pathway is activated when PMNs are given arachidonic acid in ethanol and there is extensive metabolism to 5-hydroxyicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4). This activation event was shown to be altere...
متن کاملChemoattractant - Mediated Stimulation of the Respiratory Burst in Human Polymorphonuclear Leukocytes May Require Appearance
Low doses of aliphatic alcohols produce divergent effects on the function of chemoattractant receptors on human polymorphonuclear leukocytes (PMNs) since they enhance chemotaxis but inhibit stimulation of superoxide production by chemoattractants. As such. alcohols can provide useful pharmacologic tools to probe the mechanisms of stimulus-response coupling in leukocytes. A role for protein kina...
متن کاملChemoattractant - Mediated Stimulation of the Respiratory Burst in Human Polymorphonuclear Leukocytes May Require
Low doses of aliphatic alcohols produce divergent effects on the function of chemoattractant receptors on human polymorphonuclear leukocytes (PMNs) since they enhance chemotaxis but inhibit stimulation of superoxide production by chemoattractants. As such. alcohols can provide useful pharmacologic tools to probe the mechanisms of stimulus-response coupling in leukocytes. A role for protein kina...
متن کاملChemotaxis by polymorphonuclear leukocytes
The ability of a cell or organism to direct its movement along a chemical gradient has fascinated biologists for over 100 yr. This process of chemotaxis requires transformation of directional information from the environment into a series of cellular responses resulting in directional movement. Many lower organisms including bacteria, protozoa, and slime molds exhibit chemotaxis. This ability h...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Ensho
سال: 1997
ISSN: 0389-4290,1884-4006
DOI: 10.2492/jsir1981.17.231